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style="text-indent: 2em;">近日，中国农业科学院<a target="_blank">饲料研究所</a>饲料加工与质量安全创新团队系统阐明了大口黑鲈RELA蛋白的乙酰化修饰新位点，并揭示了SIRT7介导的RELA去乙?；奘慰捎行У骺馗卧嘌字⒑拖宋Ｏ喙匮芯糠⒈碓凇逗Ｑ笊锟蒲в爰际酰∕arine Life Science & Technology）》。</p> <p style="text-indent: 2em;">在当前鱼粉资源紧缺、豆粕使用受限的背景下，提高淀粉在肉食性鱼类饲料中的供能比例，已成为推动水产养殖业可持续发展的关键策略。然而，高淀粉饲料易诱发大口黑鲈代谢性肝病，表现为肝脏脂质沉积、炎症风暴以及纤维化，其分子机制及干预靶点尚不明确。</p> <p style="text-indent: 2em;">研究发现，高淀粉饲料在诱导肝脏炎症和纤维化的同时，RELA蛋白的乙酰化水平显著下调。实验表明，K119是RELA蛋白关键的乙?；奘挝坏?，其去乙酰化不仅增强了RELA的核定位和DNA结合活性，还显著提升其转录活性，进而促进炎症相关靶基因表达和肝脏纤维化进程。进一步研究表明，去乙?；窼IRT7是介导RELA蛋白K119位点去乙?；墓丶浮IRT7的过表达可显著降低RELA蛋白乙?；讲⒃銮科渥蓟钚裕鳶IRT7抑制则产生相反效应。值得注意的是，SIRT7特异性抑制剂可恢复脂多糖及高糖高脂饲料引起的RELA蛋白乙酰化水平下降，抑制其核定位和其下游基因表达，从而有效减轻大口黑鲈急性与慢性肝脏炎症及纤维化。</p> <p style="text-indent: 2em;">该研究得到国家自然科学基金等项目的资助。（通讯员：高鸽）</p> <p style="text-indent: 2em;">原文链接：https://link.springer.com/article/10.1007/s42995-025-00287-9</p> <p class="gpCmsImg" style="text-align: center;"><img src="../../images/2025-04/614177a40a4b4899aa310718106002a2.jpg" 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